Future of High-Density Lipoprotein Infusion Therapies

Future of high-density lipoprotein infusion therapies: potential for clinical management of vascular disease.

1112 T he field of high-density lipoprotein (HDL) therapeutics is broadly aimed at combating the significant residual cardiovascular risk remaining after effective low-density lipoprotein (LDL) cholesterol reduction. 1 After the recent failure of 3 orally active HDL-raising agents in prospective intervention trials, including 2 in the cholesteryl ester transfer protein (CETP) inhibitor class 2,...

Therapies for raising high-density lipoprotein cholesterol.

A low high-density lipoprotein cholesterol (HDL-C) level is one of the strongest predictors of coronary risk (1). The negative correlation between coronary artery disease (CAD) and plasma HDL-C has been attributed to the ability of HDL to take up cellular cholesterol from the periphery and to mediate the transport of excess cholesterol to the liver (reverse cholesterol transport, RCT) (2). In J...

High-density lipoprotein and coronary heart disease: current and future therapies.

Coronary heart disease remains a major cause of worldwide morbidity and mortality despite therapeutic advances that control many risk factors such as low-density lipoprotein cholesterol to levels lower than previously possible. Population studies have consistently demonstrated an inverse association between high-density lipoprotein cholesterol (HDL-C) levels with the risk of coronary heart dise...

Novel therapies focused on the high-density lipoprotein particle.

Cardiovascular disease (CVD) remains a major burden for morbidity and mortality in the general population, despite current efficacious low-density lipoprotein-cholesterol-lowering therapies. Consequently, novel therapies are required to reduce this residual risk. Prospective epidemiological studies have shown that high-density lipoprotein-cholesterol (HDL-C) levels are inversely correlated with...

Reconstituted high-density lipoprotein therapies: a cause for optimism.